09 de febrero 2022
Abstract:
Misfolding, aggregation, and deposition of proteins in the nervous system are common features of several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and prion diseases, among others. Aging is the most relevant risk factor for all these diseases and recent evidence suggests that the buffering capacity of the proteostasis network decreases with aging and contributes to the etiology of these neuropathologies (Martinez et al., 2017). In this Research Topic, we have compiled a list of interesting manuscripts which describe protein misfolding and proteostasis impairment in aging and neurodegeneration.