Parra, Mario Alfredo, Sandra Baez, Lucas Sedeño, Cecilia Gonzalez Campo, Hernando Santamaría-García, Ivan Aprahamian, Paulo HF Bertolucci, Julian Bustin, Maria Aparecida Camargos Bicalho, Carlos Cano-Gutierrez, Paulo Caramelli, Marcia L. F. Chaves, Patricia Cogram, Bárbara Costa Beber, Felipe A. Court, Leonardo Cruz de Souza, Nilton Custodio, Andres Damian, Myriam de la Cruz, Roberta Diehl Rodriguez, Sonia Maria Dozzi Brucki, Lais Fajersztajn, Gonzalo A. Farías, Fernanda G. De Felice, Raffaele Ferrari, Fabricio Ferreira de Oliveira, Sergio T. Ferreira, Ceres Ferretti, Marcio Luiz Figueredo Balthazar, Norberto Anizio Ferreira Frota, Patricio Fuentes, Adolfo M. García, Patricia J. Garcia, Fábio Henrique de Gobbi Porto, Lissette Duque Peñailillo, Henry Willy Engler, Irene Maier, Ignacio F. Mata, Christian Gonzalez-Billault, Oscar L. Lopez, Laura Morelli, Ricardo Nitrini, Yakeel T. Quiroz, Alejandra Guerrero Barragan, David Huepe, Fabricio Joao Pio, Claudia Kimie Suemoto, Renata Kochhann, Silvia Kochen, Fiona Kumfor, Serggio Lanata, Bruce Miller, Leticia Lessa Mansur, Mirna Lie Hosogi, Patricia Lillo, Jorge Llibre Guerra, David Lira, Francisco Lopera, Adelina Comas, José Alberto Avila-Funes, Ana Luisa Sosa, Claudia Ramos, Elisa de Paula França Resende, Heather M. Snyder, Ioannis Tarnanas, Jenifer Yokoyama, Juan Llibre, Juan Felipe Cardona, Kate Possin, Kenneth S. Kosik, Rosa Montesinos, Sebastian Moguilner, Patricia Cristina Lourdes Solis, Renata Eloah de Lucena Ferretti-Rebustini, Jeronimo Martin Ramirez, Diana Matallana, Lingani Mbakile-Mahlanza, Alyne Mendonça Marques Ton, Ronnielly Melo Tavares, Eliane C Miotto, Graciela Muniz-Terrera, Luis Arnoldo Muñoz-Nevárez, David Orozco, Maira Okada de Oliveira, Olivier Piguet, Maritza Pintado Caipa, Stefanie Danielle Piña Escudero, Lucas Porcello Schilling, André Luiz Rodrigues Palmeira, Mônica Sanches Yassuda, Jose Manuel Santacruz-Escudero, Rodrigo Bernardo Serafim, Jerusa Smid, Andrea Slachevsky, Cecilia Serrano, Marcio Soto-Añari, Leonel Tadao Takada, Lea Tenenholz Grinberg, Antonio Lucio Teixeira, Maira Tonidandel Barbosa, Dominic Trépel, and Agustin Ibanez. Dementia in Latin America: Paving the way toward a regional action plan. Alzheimer’s & Dementia, 2020; 1– 19. https://doi.org/10.1002/alz.12202
20 de noviembre 2020
Abstract:
Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC‐CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence‐based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.
